Role of Love Hormone Oxytocin In Male Sexual Function Discovered

Japanese researchers have come closer to determining the precise ways in which oxytocin – commonly known as ‘the love hormone’ – plays in male sexual function. Their new study appears to confirm that oxytocin can increase not only sexual activity in males, but also the number and strength of male erections.

It’s been known that sperm ejaculation in both human males, and in small rodents such as rats, is controlled via nerve impulses in the spinal column. It had been previously thought that oxytocin in the brain triggers in some way the required nerve activity in the spinal column for erection and ejaculation to happen. The exact way in which this happened was unclear. Now it appears that this latest study, conducted on male rats at Okayama University in Japan, has shed light on the precise methods by which the love hormone in the brain, transmits down to the spinal column, and results in erections and ejaculations in the penis. The researchers, led by Professor Sakamoto, expressed hope that their findings may result in treatments for male sexual dysfunction.

Oxytocin is transferred from the brain to various parts of the body by the blood, and from neuron to neuron through structures called “synapses.” However, the precise mechanisms by which sparsely dispersed oxytocin fibers–structures responsible for responding to oxytocin in the central nervous system–cause the activation of widely distributed receptors remain unclear.

The researchers from Japan investigated a novel non-synaptic mode of oxytocin transport across the central nervous system. When asked to explain this process, Prof Sakamoto refers to an interesting analogy: “Overall, the endocrine system, which acts on widespread distant organs via the circulation, resembles a ‘broadcasting satellite’ communication, whereas synaptic transmission resembles the hard-wired ‘ethernet.’ Accordingly, the localized volume transmission of peptides resembles ‘Wi-Fi’ communication, since it is a hybrid of both endocrine (satellite) and synaptic (ethernet) systems, and may be the predominant mechanism of oxytocinergic modulation of socio-sexual behavior and cognition throughout the central nervous system.”

It is already known that spinal regions like the spinal ejaculation generator (SEG) are known to control sexual functions in male rodents. To assess the role of oxytocin in copulatory and ejaculatory responses, the team injected oxytocin into the spine of male rats. The gastrin-releasing peptide or GRP neurons are an important component of the SEG, as they control the lower lumbar region connected to muscles at the base of the penis, thereby controlling erection and ejaculation.

Oxytocin caused an increased sexual activity and neuronal activity in injected animals. More specifically, oxytocin was found to directly activate SEG/GRP neurons via oxytocin receptors, which detect oxytocin, and influence male sexual function in the rat lumbar spinal cord. Using an oxytocin receptor antagonist, which reduces the activity of oxytocin receptors, resulted in a latency and decrease in number of sexual activity and ejaculatory responses in majority of the animals, confirming the importance of oxytocin.

The question remained about the transport of oxytocin, however. Electron microscopy images acquired from slices of the lumbar region ruled out the presence of synaptic vesicles or connections. Upon stimulation of exocytosis ex-vivo, they were able to observe oxytocin transport mediated by a more passive diffusion in extracellular spaces at non-synaptic sites.

Highlighting the importance of the study, Prof Sakamoto remarks, “Now that we have uncovered a novel neural mechanism-the ‘localized volume transmission’ of oxytocin from axons-involved in controlling male sexual function in the spinal cord, we can hope that this may lead to the development of treatments for male sexual dysfunction.”

This study thus presents a completely unprecedented role for oxytocin in male sexual function, in addition to its long-standing “female-centric” role. Learning more about this “love hormone” may indeed help us foster healthier and long-lasting loving relationships!

https://www.eurekalert.org/pub_releases/2020-11/ou-lbo111820.php

Oxytocin Could Reverse Alzheimers and Treat Other Cognitive Disorders

Many studies have already shown that the ‘love hormone’ oxytocin could play a role in treating cognitive disorders that range from autism to schizophrenia. A promising new study published last month by researchers at the Tokyo University of Science suggests it could even reverse Alzheimer’s disease. That terrible ailment that afflicts so many elderly people across the world, is known to have as one of its causes a build up in the brain of the protein amyloid β. It is thought that this protein affects the signaling ability of neurons in the brain. In this latest study using mouse models, it appeared that oxytocin somehow reverses the degradation of this neuronal signaling ability caused by the build up of amyloid β, although exactly how it manages this feat is yet to be established.

According to a report in Science Daily :

Prof Saitoh remarks, “This is the first study in the world that has shown that oxytocin can reverse Aβ-induced impairments in the mouse hippocampus.” This is only a first step and further research remains to be conducted in vivo in animal models and then humans before sufficient knowledge can be gathered to reposition oxytocin into a drug for Alzheimer’s. But, Prof Saitoh remains hopeful. He concludes, “At present, there are no sufficiently satisfactory drugs to treat dementia, and new therapies with novel mechanisms of action are desired. Our study puts forth the interesting possibility that oxytocin could be a novel therapeutic modality for the treatment of memory loss associated with cognitive disorders such as Alzheimer’s disease. We expect that our findings will open up a new pathway to the creation of new drugs for the treatment of dementia caused by Alzheimer’s disease.”

Although oxytocin is not a pheromone, it is a hormone molecule that does appear to have a similar role in mating and attraction, in that it appears to influence these social behaviors (and many others) in an invisible way and can be transmitted internasally from person to person.

Social Distancing Is Playing With Our Hormones

Social distancing is likely playing around with our oxytocin levels – the ‘love hormone’ that plays a key role in bonding, trust, and human relationships. However, it’s not clear if it’s as straightforward as one might think. Although social interaction is known to raise oxytocin, research has also indicated that social isolation and stress can also raise oxytocin levels, presumably as a means to encourage the seeking out of social contacts.

While the impact of social isolation on levels of the love hormone is unclear, oxytocin has been linked to various objective markers of good health, such as reduced blood pressure and heart rate. It’s clearly a good thing for your body to be producing in these locked down times, so how can you raise it naturally when social distancing rules are in place?

While video chat apps such as Zoom and FaceTime cannot completely replace human contact, they are the next best thing in raising oxytocin levels healthily and naturally, as they allow eye contact and a real feeling of connecting to another person.

Writing in Psychology Today, Erin Leyba advises more frequent hugs for family members, and if physical contact is not possible, then regular chats on Zoom or other video conferencing apps.

Oxytocin Could Be Used to Treat Social Anxiety and Autism

Oxytocin is a hormone that works in something of a similar way to pheromones. One of the key differences is that oxytocin is not a ‘sexual communicator’ per se, but rather is produced by the body in order to regulate more general feelings of social trust and bonding in the individual. However, like pheromones, it has been found to produce these effects when inhaled from outside of the body (for example, via a spray).

There is much excitement in the medical community that oxytocin could one day be used as an effective treatment for a wide spectrum of social disorders, ranging from social anxiety to autism and even schizophrenia. A recent study conducted by Kings College London has raised these hopes further.

Scientists at Kings College London tested the hormone on 17 healthy volunteers. The oxytocin was administered by three different routes in order to see if each method had different effects to the others – through a nasal spray, through injection into the blood stream, and via a neubulizer.

Each of them received oxytocin through injections, a normal nasal spray and a nebuliser – a mask that covers the face and delivers medicine as you breathe.

While the patients received the drug, their brain activity was measured in an MRI scanner.

Dr Paloyelis and their team observed that in all three methods of delivery, the blood flow to the amygdala – the region of the brain involved in processing social information, emotion and anxiety – was reduced.

They also found that levels of excitement and alertness decreased.

Previous studies have shown that people who suffer from anxiety show increased activity in the amygdala regions of their brains.

Therefore, reduced activity may help to ease symptoms present in social situations.

The researchers also found that administering the drug via the nasal route targeted areas of the brain which the injection method did not reach, although it was not clear where.

The scientists concluded that the use of oxytocin as a potential treatment for social disorders may depend on the specific region of the brain targeted, and that a particular method of administering the oxytocin to the desired region may be more effective than others.

Sources include : https://www.dailymail.co.uk/health/article-8069105/Oxytocin-used-medicine-help-people-anxiety-autism.html

Pet Bonding Oxytocin Spray Review

pet bonding oxytocin spray

Pet Pheromones : None – Oxytocin

Price : $39

Available To Buy From : VeroLabs

Believe it or not, but you can now buy an oxytocin spray designed to help you bond more easily with your pet, be it your dog or your cat.

The oxytocin spray, once sprayed on to the pet’s collar, should also make the animal more sociable with both people and other animals. It can also help to make your pet less anxious in stressful situations.

The ‘trust hormone’ for anxious or socially withdrawn pets

Oxytocin has been well established by numerous scientific studies to play a role in bonding and social relationships among mammals. As recently as 2017 a study in Sweden found that ‘the tendency of dogs to seek contact with their owners is associated with genetic variations in sensitivity for the hormone oxytocin’.

This unique pet bonding spray is made by the longest established company selling commercial oxytocin sprays online – VeroLabs.

Oxytocin is not a pheromone, and this product does not contain any pheromones, so there is no danger of your dog suddenly turning in to a horny pooch. Instead, it’s merely a gentle oxytocin spray that should, in theory, make the pet calmer and more confident around you, other people, and other animals.

Simply spray 3 times on the pet’s collar or other item it comes into contact with regularly.

Order From VeroLabs Now

Could Oxytocin Fix A Broken Heart?

If you’ve already been left broken hearted by your Valentine’s Day sweetheart, the answer could lie in a pill, or more likely a spray, containing the ‘love hormone’ oxytocin.

A lot of the research into oxytocin has centered around studying voles. These furry little mammals are actually quite like us when it comes to pair bonding, monogamy, and even it appears, being left broken hearted. Humans and voles belong to only around 5% of mammals that form long lasting pair bonds. For that reason, they have been the subjects of choice for scientists looking at the role oxytocin might play in human mating.

According to Larry Young, an Emory University researcher, voles show all the symptoms of being heartbroken if their partners are taken away from them in the lab.

“A vole that has been with a partner and then you take the partner away, if you put them in a beaker of water for a few minutes, they tend to just float,” he said. “If you hold them up by their tail, they just hang there. They show the signs of despair.”

They just give up on life — basically, it’s not worth it without her.

But for voles at least, there is a cure for a broken heart: oxytocin. It’s a naturally occurring hormone.

Larry Young describes how the power of oxytocin as regards pair bonding is so great, that it can make a mother see even her ugly new born child look adorable. The same molecule, he and other researchers believe, cause the vole and other mammals to form bonding relationships for mating and the rearing of offspring.

Another hormone is produced during the break up of a pair bond – the stress hormone CRF – which completely cuts off the supply of oxytocin. And therein lies the promise of a fix for a broken heart in a bottle (instead of THE bottle).

Those depressed, floating voles, the ones hanging listlessly by their tails, they’re in withdrawal. It’s because of the stress hormone, CRF.

“It really gets loaded when the animals form a bond. But it’s not released. It’s just loaded, like loading a gun,” Young said. “But then when they are away from their partner, that CRF floods into the brain.”

And CRF stops oxytocin production cold. Young thinks it’s maybe a naturally evolved kind of insurance policy. Animal partners, voles and humans, have to spend some time apart to forage seeds or go to class or whatever. That CRF is part of what bums you out, makes you miss the other person, and go back to them to get another fix of oxytocin.

Source : https://whyy.org/segments/science-can-cure-heartbreak-in-voles-but-what-about-in-humans/

Oxytocin May Increase Casual Sex

The ‘love hormone’ Oxytocin has long been associated by various studies with monogamous pair bonding, but a new study from China suggests it ‘may make men more interested in casual short-term flings with unfaithful partners’. And according to a report in the Daily Mail, the researchers claim that it could make sexual attraction more important than feelings of romantic attachment, at least at the start of the relationship.

After courtship ends and a relationship begins, the hormone then moves on to help build more romantic bonds, say researchers from the University of Electronic Science and Technology of China.

During the study 160 people were shown pictures of members of the opposite sex and told by researchers whether those people had been faithful or unfaithful.
Participants were then asked to give their preference for having a long-term or short-term relationship with the person in the picture.

They found that both sexes clearly prefer fidelity in a prospective long-term partner but the picture differed when it came to short-term relationships.

Men were more likely than women to say they would have a short-term relationship with someone who had been unfaithful.

Women were more likely to want a lasting relationship with a faithful man.