Role of Love Hormone Oxytocin In Male Sexual Function Discovered

Japanese researchers have come closer to determining the precise ways in which oxytocin – commonly known as ‘the love hormone’ – plays in male sexual function. Their new study appears to confirm that oxytocin can increase not only sexual activity in males, but also the number and strength of male erections.

It’s been known that sperm ejaculation in both human males, and in small rodents such as rats, is controlled via nerve impulses in the spinal column. It had been previously thought that oxytocin in the brain triggers in some way the required nerve activity in the spinal column for erection and ejaculation to happen. The exact way in which this happened was unclear. Now it appears that this latest study, conducted on male rats at Okayama University in Japan, has shed light on the precise methods by which the love hormone in the brain, transmits down to the spinal column, and results in erections and ejaculations in the penis. The researchers, led by Professor Sakamoto, expressed hope that their findings may result in treatments for male sexual dysfunction.

Oxytocin is transferred from the brain to various parts of the body by the blood, and from neuron to neuron through structures called “synapses.” However, the precise mechanisms by which sparsely dispersed oxytocin fibers–structures responsible for responding to oxytocin in the central nervous system–cause the activation of widely distributed receptors remain unclear.

The researchers from Japan investigated a novel non-synaptic mode of oxytocin transport across the central nervous system. When asked to explain this process, Prof Sakamoto refers to an interesting analogy: “Overall, the endocrine system, which acts on widespread distant organs via the circulation, resembles a ‘broadcasting satellite’ communication, whereas synaptic transmission resembles the hard-wired ‘ethernet.’ Accordingly, the localized volume transmission of peptides resembles ‘Wi-Fi’ communication, since it is a hybrid of both endocrine (satellite) and synaptic (ethernet) systems, and may be the predominant mechanism of oxytocinergic modulation of socio-sexual behavior and cognition throughout the central nervous system.”

It is already known that spinal regions like the spinal ejaculation generator (SEG) are known to control sexual functions in male rodents. To assess the role of oxytocin in copulatory and ejaculatory responses, the team injected oxytocin into the spine of male rats. The gastrin-releasing peptide or GRP neurons are an important component of the SEG, as they control the lower lumbar region connected to muscles at the base of the penis, thereby controlling erection and ejaculation.

Oxytocin caused an increased sexual activity and neuronal activity in injected animals. More specifically, oxytocin was found to directly activate SEG/GRP neurons via oxytocin receptors, which detect oxytocin, and influence male sexual function in the rat lumbar spinal cord. Using an oxytocin receptor antagonist, which reduces the activity of oxytocin receptors, resulted in a latency and decrease in number of sexual activity and ejaculatory responses in majority of the animals, confirming the importance of oxytocin.

The question remained about the transport of oxytocin, however. Electron microscopy images acquired from slices of the lumbar region ruled out the presence of synaptic vesicles or connections. Upon stimulation of exocytosis ex-vivo, they were able to observe oxytocin transport mediated by a more passive diffusion in extracellular spaces at non-synaptic sites.

Highlighting the importance of the study, Prof Sakamoto remarks, “Now that we have uncovered a novel neural mechanism-the ‘localized volume transmission’ of oxytocin from axons-involved in controlling male sexual function in the spinal cord, we can hope that this may lead to the development of treatments for male sexual dysfunction.”

This study thus presents a completely unprecedented role for oxytocin in male sexual function, in addition to its long-standing “female-centric” role. Learning more about this “love hormone” may indeed help us foster healthier and long-lasting loving relationships!

https://www.eurekalert.org/pub_releases/2020-11/ou-lbo111820.php